Current Research

Please see the menus below for information about our current research.
Anaesthetic Research
Study Title - PQIP – Improving perioperative care through the use of quality data – Patient study of the perioperative Quality Improvement Programme
Principal Investigator: Dr Kathryn Brodbelt
Research Nurses: Reni Jacob & Cathy Jones
Study Title – ALLEGRO – A placebo controlled randomised trial of intravenous lidocaine in accelerating gastrointestinal recovery after colorectal surgery
Principal Investigator: Dr Heather Black
Research Nurses: Reni Jacob & Cathy Jones
Cancer Research
Study Title - ADD-ASPIRIN - A phase III double-blind placebo-controlled randomised trial assessing the effects of aspirin on disease recurrence and survival after primary therapy in common non-metastatic solid tumours
Principal Investigator: Mr Liviu Titu (Colorectal)
Sub Investigators: Mr Nigel Parr (Prostate) and Mr Raman Vinayagam (Breast)
Research Nurse: Liz Bailey
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Study Title – ATLANTA – Adjuvant treatments to the local tumour for metastatic prostate cancer: Assessment of novel treatment algorithms
Principal Investigator: Mr Manal Kumar
Research Nurse: Anne Reddington
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Study Title – Bladderpath – Image directed redesign of bladder cancer treatment pathways
Principal Investigator: Dr Thiagarajan Nambi Rajan
Research Nurse: Jessie Huang
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Study Title – Breast Cancer in Men - A national population-based case-control study of the genetic, environment and behavioural causes of breast cancer in men.
Principal Investigator: Mr Raman Vinayagram
Research Nurse: Liz Bailey
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Study Title - EMERALD - A window of opportunity study to assess the biological effect of enobosarm in oestrogen receptor positive, androgen receptor positive early breast cancer
Principal Investigator: Mr Raman Vinayagram
Research Nurse: Liz Bailey
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Study Title - LORIS - A Phase III Trial of Surgery versus Active Monitoring for Low Risk Ductal Carcinoma in Situ (DCIS)
Principal Investigator: Mr Raman Vinayagram
Research Nurse: Liz Bailey
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Study Title – PEARL – A window of opportunity study to assess the biological effects of progesterone in premenopausal ER-positive, PgR-positive early breast cancer
Principal Investigator: Mr Raman Vinayagram
Research Nurse: Liz Bailey
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Study Title - POSNOC: Positive Sentinel NOde: adjuvant therapy alone versus adjuvant therapy plus Clearance or axillary radiotherapy. A randomised controlled trial of axillary treatment in women with early stage breast cancer who have metastases in one or two sentinel nodes
Principal Investigator: Mr Raman Vinayagram
Research Nurse: Liz Bailey
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Study Title - TIP - Thrombin Inhibition Preoperatively in Early Breast Cancer
Principal Investigator: Mr Raman Vinayagram
Research Nurse: Liz Bailey
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Study Title - UK Genetic Prostate Cancer Study (UKGPCS)
Principal Investigator: Dr Nigel Parr
Research Nurse: TBC
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Critical Care Research
Study Title - The A-STOP Study - Antifungal stewardship opportunities with rapid tests for fungal infection in critically ill patients
Principal Investigator: Dr Paul Jeanrenaud
Research Nurses: Reni Jacob & Cathy Jones
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Study Title – POETICS 2 - Prospective study on over eighty year old Intensive Care patients.
Principal Investigator: Reni Jacob
Research Nurses: Reni Jacob & Cathy Jones
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Dermatology Research
BADBIR -British Association of Dermatologists Biologic Interventions Register
Principal Investigator: Dr W Farrar
Gastroenterology Research
Study Title – Records keeping in IBD
Principal Investigator: Dr Paul Flanagan
Research Nurse: Liz Bailey
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Haematology Research
Study Title - AML L1 - Leukaemia Lymphoma Research and NCRI Working Group Programme
Principal Investigator: Dr Ranjit Dasgupta
Research Nurse: Jessie Huang
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Study Title - AML 18 - A Trial for Older Patients with Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome
Principal Investigator: Dr Ranjit Dasgupta
Research Nurse: Jessie Huang
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Study Title - AML 19 - A national cancer research institute acute myeloid leukaemia (AML) working group pilot trial to establish the feasibility of combining tyrosine kinase inhibitor, ponatinib with chemotherapy in patients with AMLwith a flt3 mutation.
Principal Investigator: Dr Ranjit Dsagupta
Research Nurse: Jessie Huang
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Study Title - MAPLE- Molecular profiling for lymphoma
Principal Investigator: Dr Barbara Hammer
Research Nurse: Jessie Huang
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Study Title - MCL Biobank - Establishing a Biobank and Database as a National Resource for Characterising Indolent and Aggressive forms of Mantle Cell Lymphoma, an Observational Study.
Principal Investigator: Dr Barbara Hammer
Research Nurse: Jessie Huang
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Study Title - MEASURES - The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative Neoplasms.
Principal Investigator: Dr Elizabeth Jones
Research Nurse: Jessie Huang
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Study Title – National cohort study of late effects of Hodgkin lymphoma treatment
Principal Investigator: Dr Barbara Hammer
Research Nurse: Jessie Huang
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Neonatal Research
BABY OSCAR - Outcome After Selective Early Treatment for Closure of Patent Ductus Arteriosus in Preterm Babies
Principal Investigator: Dr Anand Kamalanthan
Research Nurses: Sharon Hughes and Lucy Lewis
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OPTI-PREM – Optimising Neonatal Service provision for preterm babies born between 27 and 31 weeks of gestation in England, using national data, qualitative research and economic analysis
Principal Investigator: N/A
Research Nurses: Lucy Lewis and Sharon Hughes
Orthopaedic Research
Study Title - Achilles Tendinopathy Management (ATM) - A multi-centre placebo controlled randomised controlled trial comparing Platelet Rich Plasma (PRP) to placebo (imitation) injection in adults with Achilles tendon pain.
Principal Investigator: Mr Michael Hennessy
Research Nurses: Mandy Edwards
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Study Title - Investigating Molecular & Cellular Biology Mechanisms in Articular Cartilage
Principal Investigator: Mr Richard Parkinson
Research Nurses: N/A
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Parkinson’s Disease Research
PROBAND - Parkinson's Repository of Biosamples and Network Datasets
Principal Investigator: Dr Mary O’Neill
Research Nurse: Andrea Young
Paediatric Research
Study Title - ADDRESS 2 - An incident and high risk type 1 diabetes research cohort After Diagnosis Diabetes Research Support System
Principal Investigator: Dr C De Silva
Research Nurses: Lucy Lewis and Sharon Hughes
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Study Title - Baby Oscar - Outcome After Selective Early Treatment for Closure of Patent Ductus Arteriosus in Preterm Babies
Principal Investigator: Dr Anand Kamalanathan
Research Nurses: Lucy Lewis and Sharon Hughes
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Study Title - CF Start - The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF.
Principal Investigator: Dr David Lacy
Research Nurses: Lucy Lewis and Sharon Hughes
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Study Title - FADES - Feeding and Autoimmunity in Down's syndrome Evaluation Study
No Local Investigator: This trust is a Participant Identification Centre only
Research Nurses: Lucy Lewis and Sharon Hughes
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Study Title - OPTI-PREM – Optimising Neonatal Service provision for preterm babies born between 27 and 31 weeks of gestation in England, using national data, qualitative research and economic analysis
Principal Investigator: Dr Anand Kamalanathan
Research Nurses: Lucy Lewis and Sharon Hughes
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Study Title – PiC – Petechiae in Children (PIC) Study: defining a clinical decision rule for the management of fever and non-blanching rashes in children including the role of point of care testing for procalcitonin & neisseria meningitidis DNA
Principal Investigator: Dr Santosh Keshavamurthy
Research Nurses: Lucy Lewis and Sharon Hughes
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Study Title – RAACENO – Reducing Asthma Attacks in Children using Exhaled Nitric Oxide as a biomarker to inform treatment strategy - a randomised trial
Principal Investigator: Dr Sudeshna Bhowmik
Research Nurses: Lucy Lewis and Sharon Hughes
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Study Title – Science - Surgery or Cast for Injuries of the epicondyle in children’s elbows
Principal Investigator: Mr Simon Robinson
Research Nurses: Lucy Lewis and Sharon Hughes
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Study Title - UK Childhood ITP Registry
Principal Investigator: Dr Oliver Rackham
Research Nurses: Lucy Lewis and Sharon Hughes
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Renal Research
Study Title - PURE - The clinical and cost effectiveness of surgical interventions for stones in the lower pole of the kidney: The Percutaneous nephrolithotomy, flexible Ureterorenoscopy and Extracorporeal shockwave lithotripsy for lower pole kidney stones Randomised Controlled Trial
Principal Investigator: Mr Snahel Patel
Research Nurse: Reni Jacob and Cathy Jones
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Study Title - RADAR - National Registry of Rare Kidney Diseases
Principal Investigator: Dr Thomas Ledson
Research Nurse: Reni Jacob and Cathy Jones
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Study Title – SIMPLIFIED - Survival Improvement with Cholecalciferol in Patients on Dialysis
Principal Investigator: Dr Thomas Ledson
Research Nurse: Reni Jacob and Cathy Jones
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Study Title - The UK Calciphylaxis Study
Principal Investigator: Dr Noshaba Naz
Research Nurse: Reni Jacob and Cathy Jones
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Reproductive Health Research
Study Title - ALIFE 2 - Anticoagulants for Living FoEtuses in women with recurrent miscarriage and inherited thrombophilia
Principal Investigator: Mr Michael Ellard
Research Midwife: Julie Grindey
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Study Title - C-STICH - The Cerclage Suture Type for an Insufficient Cervix and its effect on Health outcomes (C-STICH) Trial: A Randomised Controlled Trial of monofilament versus braided sutures for insufficient cervix.
Principal Investigator: Miss Rajeshwari Myagerimath
Research Midwife: Julie Grindey
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Study Title - FUTURE - Female Urgency, Trial of Urodynamics as Routine Evaluation (FUTURE study); a superiority randomised clinical trial to evaluate the effectiveness and cost effectiveness of invasive urodynamic investigations in management of women with refractory overactive bladder symptoms.
Principal Investigator: Mr Mark Doyle
Research Midwife: Julie Grindey
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Study Title – SUPPORT - Stitch, Progesterone or Pessary: a Randomised Trial
Principal Investigator: Ms Rajeshwari Myagerimath
Research Midwife: Julie Grindey
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Study Title – TTTS – Multiple Pregnancy Registry
Principal Investigator: Ms Rajeshwari Myagerimath
Research Midwife: Julie Grindey
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Respiratory Research
ASAP - Early low dose steroids for adults admitted to hospital with influenza-like illness during a pandemic: a randomised placebo controlled trial
Principal Investigator: Dr A Wright
Research Nurse: Liz Bailey
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EMBARC - The European Bronchiectasis Registry
Principal Investigator: Dr N Stevenson
Research Nurse: Liz Bailey
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Study Title – BICS - A randomised, double-blind placebo controlled trial of the effectiveness of the beta-blocker bisoprolol in preventing exacerbations of COPD
Principal Investigator: Dr David Tarpey
Research Nurse: Liz Bailey
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Rheumatology Research
Study Title - BSRBR Register - Prospective observational study of the long term hazards of biologic therapy in rheumatoid arthritis
Principal Investigator: N/A
Research Nurse: Julie McEntee
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Study Title - CREDO 4 – A Multi-centre, Open-Label, Phase III Study of the Efficacy and Safety of Olokizumab in Subjects with Moderately to Severely Active Rheumatoid Arthritis.
Principal Investigator: Dr Emmanuel George
Research Nurse: Julie McEntee
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Study Title - GCA Consortium - Clinical and immunogenetic characterization of Giant Cell Arteritis (GCA) and polymyalgia rheumatica (PMR)
Principal Investigator: Dr Emmanuel George
Research Nurse: Julie McEntee
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Study Title - Inflammatory Signaling Pathways
Principal Investigator: Dr Emmanuel George
Research Nurse: Julie McEntee
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Study Title: British Society for Rheumatology Psoriatic Arthritis Register
Principal Investigator: Dr Emmanuel George
Research Nurse: Julie McEntee
Stroke Research
Study Title – ELAN - Early versus Late initiation of direct oral Anticoagulants in post-ischaemic stroke patients with atrial fibrillation: an international, multicentre, randomised-controlled, two-arm, assessor-blinded trial
Principal Investigator: Dr Brian Menezes
Research Nurse: Venetia Johnson
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Study Title - Optimizing prediction of stroke outcome using brain imaging machine- e-learning.
Principal Investigator: Dr Ruth Davies
Research Nurse: Venetia Johnson
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Study Title - Patient and Carer Experience of Post-Stroke Motor Apraxia
Principal Investigator: Dr Ruth Davies
Research Nurse: Venetia Johnson
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Study Title - PRECIOUS - Prevention of complications to Improve outcome in elderly patients with acute stroke. A randomised, open, phase III, clinical trial with blinded outcome assessment.
Principal Investigator: Dr Ruth Davies
Research Nurse: Venetia Johnson
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Study Title – RV4AD - Rates, Risks and Routes to Reduce Vascular Dementia
Principal Investigator: Dr Ruth Davies
Research Nurse: Venetia Johnson
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Study Title – So-START - Start or stop anticoagulants randomised trial after spontaneous intracranial haemorrhage
Principal Investigator: Dr Brian Menezes
Research Nurse: Venetia Johnson
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Study Title – TWIST - randomised-controlled trial of thrombolytic treatment with tenecteplase for acute ischaemic stroke upon awakening
Principal Investigator: Dr Ruth Davies
Research Nurse: Venetia Johnson
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Surgery Research
Study Title – ROSSINI 2 – A Phase III, multi-arm, multi-stage (MAMS) pragmatic, blinded (patient and outcome assessor) multicentre, randomised controlled trial (RCT) with an internal pilot, to evaluate the use of three in-theatre interventions, alone or in combination, to reduce SSI rates in patients undergoing abdominal surgery
Principal Investigator: Mr Liviu Titu
Research Nurse: Anne Reddington
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Vascular Research
Study Title - Tomographic ultrasound for the detection of complications following surgically created arterio-venous fistulae for haemodialysis
Principal Investigator: Mr Ramasubramanyan Chandrasekar
Research Nurse: N/A
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Colorectal
Study Title - The CIPHER Study - UK Cohort study to investigate the prevention of parastomal Hernia
Principal Investigator: Mr Ciaran Walsh
Research Nurse: Helyn Evans
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Study Title - PITSTOP – PIlonidal sinus treatment: studying the options
Principal Investigator: Mr Jeremy Wilson
Research Nurse: Anne Reddington
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Study Title – PPAC2 – The impact of postoperative Packing of Perianal Abscess Cavities: a multicentre randomised controlled trial
Principal Investigator: Mr Liviu Titu
Research Nurse: Anne Reddington
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Microbiology
Study Title – ARK – Antibiotic Review Kit for Hospitals
Principal Investigator: Dr David Harvey
Research Nurse: N/A
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