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Wirral University Hospital NHS Foundation Trust

Follicular lymphoma

PETReA

 

What is the study about?

The study is trying to improve treatment for people with follicular lymphoma who need drug treatment for the first time. The study is using a type of body scan called PET-CT to split patients into two groups based on how long their disease is likely to stay away after initial treatment. Those patients whose disease is likely to come back sooner rather than later will be randomly assigned to one of two types of extended treatment, while those whose disease is likely to stay away for a long time will be randomly assigned to receive extended treatment or no further treatment to see how the pros and cons of the two approaches balance out.

 

Who can take part?

People with follicular lymphoma who need drug treatment for the first time aged over 18 years.

 

Hospital visits

 

You see a doctor and have some tests before taking part. The tests might include:

  • a physical examination
  • blood tests
  • heart trace (ECG)
  • heart scan (ECHO) 
  • CT scan and PET-CT scan
  • a bone marrow test

During treatment, you see the trial team regularly. How often you see them depends on the treatment you have. You have a physical examination and blood tests each time you see them.

You have a CT scan before and after induction treatment, and every year after you finish treatment. You also have a PET-CT scan:

  • before the start of induction treatment
  • 6 weeks after you finish induction treatment
  • a year after the start of maintenance treatment if you have a positive PET-CT scan after the induction treatment

When you finish treatment, you see the trial team every 6 months. This continues for as long as you don’t have any signs of the lymphoma coming back.

You stop this study if your lymphoma comes back. Your doctor can tell you which other treatments you might have.

Further details here.

 

More information

Please visit the study website.