What is this study about?

Preterm birth (PTB) happens when a baby is born before 37 weeks of pregnancy. About 10% of

babies are born preterm worldwide. PTB can have a serious impact on the lives and health of

children and families. Researchers have found specific genetic factors related to PTB, but we

still do not fully understand the causes of PTB, or why some people are more likely to have a

PTB compared to others.

 

The aim of this is to find out which genetic features in people from different ethnic backgrounds

are linked to PTB, using whole Genome sequencing technology. We hope that this study can

help us better predict and understand PTB, so that health complications can be avoided or

reduced.

 

A genome is the body’s ‘instruction manual’ and contains all the information needed to make

you, run you and repair you. It is unique to you, and you inherit it from your parents. It is made

of DNA and is written within DNA’s special code.

 

Who can take part?

Biological mothers (over 18 years old) who have had a spontaneous preterm birth (between

16+0 and 36+6 weeks of gestation) in a current or previous pregnancies with various ethnic

backgrounds

 

What is involved?

• A one-off visit to the hospital, which will take around 30minutes
• Sign a consent form
• Collection of one blood sample approximately 3mls
• We will need to collect information about your pregnancy and birth

 

How do I take part?

Contact the Research Midwives

Julie Grindey (07768 490736) or Annie Clarke (07776 559890)

 

If you are travelling to the hospital solely to take part in the study and are not currently

receiving maternity care you will be offered reimbursement for your travel expenses.

 

Recruitment ends 30/09/2025